Protein Family Models for Protein (Select 447074599) - Protein Family Models

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Items: 6

Select item 4122991.

Tpt1 catalyses the last step of tRNA splicing in yeast. It transfers the splice junction 2'-phosphate from ligated tRNA to NAD, to produce ADP-ribose 1"-2"-cyclic phosphate. This is presumed to be followed by a transesterification step to release the RNA. The first step of this reaction is similar to that catalysed by some bacterial toxins. E. coli KptA and mouse Tpt1 are likely to use the same reaction mechanism [1]. [1]. 9915792. Transient ADP-ribosylation of a 2'-phosphate implicated in its removal from ligated tRNA during splicing in yeast. Spinelli SL, Kierzek R, Turner DH, Phizicky EM;. J Biol Chem 1999;274:2637-2644. (from Pfam)

GO Terms:

Molecular Function:: NAD+-protein poly-ADP-ribosyltransferase activity (GO:0003950)

Molecular Function:: transferase activity (GO:0016740)

Date:: 2024-10-16

Family Accession:: NF014001.5
Method:: HMM

Select item 3899372.

new record, indexing in progress

Family Accession:

Select item 3476303.

new record, indexing in progress

Family Accession:

Select item 1767574.

RNA 2'-phosphotransferase

RNA 2'-phosphotransferase catalyzes the final step of tRNA splicing, in which the 2'-phosphate on a tRNA substrate is ADP-ribosylated, releasing nicotinamide and forming ADP-ribosylated tRNA as a reaction intermediate, followed by formation of dephosphorylated, mature tRNA along with ADP ribose 1'',2''-cyclic phosphate