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CDP-alcohol phosphatidyltransferase family protein
All of these members have the ability to catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond. [1]. 8917447. Two-dimensional 1H-NMR of transmembrane peptides from. Escherichia coli phosphatidylglycerophosphate synthase in. micelles.. Morein S, Trouard TP, Hauksson JB, Rilfors L, Arvidson G,. Lindblom G;. Eur J Biochem 1996;241:489-497. (from Pfam)
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase catalyzes the committed step in the synthesis of acidic phospholipids
Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase.
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