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bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes [1]. [1]. 9244280. Identification and characterization of an operon in Salmonella typhimurium involved in thiamine biosynthesis. Petersen LA, Downs DM;. J Bacteriol 1997;179:4894-4900. (from Pfam)
hydroxyethylthiazole kinase
hydroxyethylthiazole kinase catalyzes the phosphorylation of the hydroxylgroup of 4-methyl-5-beta-hydroxyethylthiazole
Catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP
This model represents the hydoxyethylthiazole kinase, ThiM, of a number of bacteria, and C-terminal domains of bifunctional thiamine biosynthesis proteins of Saccharomyces cerevisiae and Schizosaccharomyces pombe, in which the N-terminal domain corresponds to the bacterial thiamine-phosphate pyrophosphorylase (EC 2.5.1.3), ThiE.
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