Protein Family Models

This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold. (from Pfam)

Date:

2024-08-14

This family consists of several bacterial and phage Ail/Lom-like proteins. The Yersinia enterocolitica Ail protein is a known virulence factor. Proteins in this family are predicted to consist of eight transmembrane beta-sheets and four cell surface-exposed loops. It is thought that Ail directly promotes invasion and loop 2 contains an active site, perhaps a receptor-binding domain [1]. The phage protein Lom is expressed during lysogeny, and encode host-cell envelope proteins. Lom is found in the bacterial outer membrane, and is homologous to virulence proteins of two other enterobacterial genera. It has been suggested that lysogeny may generally have a role in bacterial survival in animal hosts, and perhaps in pathogenesis [2]. [1]. 11555286. Identification of regions of Ail required for the invasion and serum resistance phenotypes. Miller VL, Beer KB, Heusipp G, Young BM, Wachtel MR;. Mol Microbiol 2001;41:1053-1062. [2]. 2144037. A bacterial virulence determinant encoded by lysogenic coliphage lambda. Barondess JJ, Beckwith J;. Nature 1990;346:871-874. (from Pfam)

Date:

2024-10-16