Protein Family Models

This entry is found at the C-terminal of Nitric oxide-associated protein 1 (NOA1) from animals and rice, BPG2 from Arabidopsis and YqeH from B. subtilis. YqeH is an orthologue of NOA1. This domain has a beta-sandwich structure with homology to the RNA-binding regulator TRAP, and the hypoxia factor pVHL. The residues for RNA recognition in TRAP are conserved in members of this entry, suggesting that these are G-proteins that may regulate nucleic acid recognition [1]. Paper describing PDB structure 3ec1. [1]. 18801747. The structure of YqeH. An AtNOS1/AtNOA1 ortholog that couples GTP hydrolysis to molecular recognition. Sudhamsu J, Lee GI, Klessig DF, Crane BR;. J Biol Chem. 2008;283:32968-32976. (from Pfam)

Date:

2024-10-16

RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern [1]. [1]. 12220175. YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics. Daigle DM, Rossi L, Berghuis AM, Aravind L, Koonin EV, Brown ED;. Biochemistry. 2002;41:11109-11117. (from Pfam)

Gene:

rsgA

Date:

2024-10-16

This HMM identifies the P-loop-containing domain of large numbers of GTPases with ribosome-associated functions, including many involved in ribosome maturation (Der, Era, etc), ribosome rescue (HflX), and protein translation (InfB, Tuf, PrfC).

Date:

2024-10-16

GTPase_YqeH family protein

Date:

2017-03-02

This family describes YqeH, a member of a larger family of GTPases involved in ribosome biogenesis. Like YqlF, it shows a cyclical permutation relative to GTPases EngA (in which the GTPase domain is duplicated), Era, and others. Members of this protein family are found in a relatively small number of bacterial species, including Bacillus subtilis but not Escherichia coli.

Gene:

yqeH

Date:

2021-04-27