Protein Family Models

This family includes single stranded binding proteins. They play an important role in DNA replication, recombination and repair. Paper describing PDB structure 1eqq. [1]. 10731701. Roles of functional loops and the C-terminal segment of a single-stranded DNA binding protein elucidated by X-Ray structure analysis. Matsumoto T, Morimoto Y, Shibata N, Kinebuchi T, Shimamoto N, Tsukihara T, Yasuoka N;. J Biochem. 2000;127:329-335. Paper describing PDB structure 1eyg. [2]. 10932248. Structure of the DNA binding domain of E. coli SSB bound to ssDNA. Raghunathan S, Kozlov AG, Lohman TM, Waksman G;. Nat Struct Biol. 2000;7:648-652. Paper describing PDB structure 1kaw. [3]. 9192620. Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution. Raghunathan S, Ricard CS, Lohman TM, Waksman G;. Proc Natl Acad Sci U S A 1997;94:6652-6657. Paper describing PDB structure 1se8. [4]. 15159541. Crystal structure of the Deinococcus radiodurans single-stranded DNA-binding protein suggests a mechanism for coping with DNA damage. Bernstein DA, Eggington JM, Killoran MP, Misic AM, Cox MM, Keck JL;. Proc Natl Acad Sci U S A. 2004;101:8575-8580. Paper describing PDB structure 1sru. [5]. 15169953. The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA. Savvides SN, Raghunathan S, Futterer K, Kozlov AG, Lohman TM, Waksman G;. Protein Sci. 2004;13:1942-1947. (from Pfam)

Date:

2024-10-16

This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA. [1]. 9192620. Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution. Raghunathan S, Ricard CS, Lohman TM, Waksman G;. Proc Natl Acad Sci U S A 1997;94:6652-6657. [2]. 9033597. Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution. Yang C, Curth U, Urbanke C, Kang C;. Nat Struct Biol 1997;4:153-157. [3]. 9271227. A common core for binding single-stranded DNA: structural comparison of the single-stranded DNA-binding proteins (SSB) from E. coli and human mitochondria. Webster G, Genschel J, Curth U, Urbanke C, Kang C, Hilgenfeld R;. FEBS Lett 1997;411:313-316. (from Pfam)

Date:

2024-10-16

PriB binds single-stranded DNA at the primosome assembly site. This HMM describes a gamma-Proteobacterial form, usually encoded between rpsF (ribosomal protein S6) and rpsR (ribosomal protein S18).

Gene:

priB

Date:

2024-05-30

primosomal replication protein N (PriB) is one of three proteins involved in the PriA-dependent replication restart system which participate in the reconstruction of the replisome by further stabilizing the PriA-DNA complex and stimulating PriA helicase activity.

Date:

2022-08-08