Protein Family Models for Protein (Select 485651403) - Protein Family Models

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Items: 6

Select item 4110791.

superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold. (from Pfam)

GO Terms:

Biological Process:: superoxide metabolic process (GO:0006801)

Molecular Function:: metal ion binding (GO:0046872)

Date:: 2024-08-14

Family Accession:: NF012309.5
Method:: HMM

Select item 3882792.

new record, indexing in progress

Family Accession:

Select item 3465913.

new record, indexing in progress

Family Accession:

Select item 3360804.

superoxide dismutase [Cu-Zn] SodC

This HMM describes the Cu,Zn-type superoxide dismutase SodC, found broadly as a periplasmic protein in Proteobacteria. The model includes both SodCI and SodCII of Salmonella, the first of which remains functional and protective after phagocytosis by macrophages and serves as a virulence factor. A disulfide bond-forming pair of Cys residues is invariant is members of this group of Cu,Zn-type superoxide dismutases.