Protein Family Models

This family includes the Type IV secretory pathway VirB3 protein, that is found associated with bacterial inner and outer membranes [2]. The family also includes the conjugal transfer protein TrbD family that contains a nucleotide binding motif and may provide energy for the export of DNA or the export of other Trb proteins [3]. [1]. 9679196. Structural characterization of the virB operon on the. hairy-root-inducing plasmid A4.. Liang Y, Aoyama T, Oka A;. DNA Res 1998;5:87-93.. [2]. 8405938. Membrane location of the Ti plasmid VirB proteins involved in. the biosynthesis of a pilin-like conjugative structure on. Agrobacterium tumefaciens.. Shirasu K, Kado CI;. FEMS Microbiol Lett 1993;111:287-294.. [3]. 8763954. The conjugal transfer system of Agrobacterium tumefaciens. octopine-type Ti plasmids is closely related to the transfer. system of an IncP plasmid and distantly related to Ti plasmid. vir genes.. Alt-Morbe J, Stryker JL, Fuqua C, Li PL, Farrand SK, Winans SC;. J Bacteriol 1996;178:4248-4257. (from Pfam)

Date:

2024-08-14

This family includes the Helicobacter pylori protein CagE Swiss:Q48252, which together with other proteins from the cag pathogenicity island (PAI), encodes a type IV transporter secretion system. The precise role of CagE is not known, but studies in animal models have shown that it is essential for pathogenesis in Helicobacter pylori induced gastritis and peptic ulceration [1]. Indeed, the expression of the cag PAI has been shown to be essential for stimulating human gastric epithelial cell apoptosis in vitro [2]. Similar type IV transport systems are also found in other bacteria. This family includes the TrbE Swiss:P54910 and VirB Swiss:P05353 proteins from the respective trb and Vir conjugal transfer systems in Agrobacterium tumefaciens. Homologues of VirB proteins from other species are also members of this family, e.g. VirB from Brucella suis Swiss:Q9RPY1. [1]. 11104802. Virulence factors of Helicobacter pylori responsible for gastric. diseases in Mongolian gerbil.. Ogura K, Maeda S, Nakao M, Watanabe T, Tada M, Kyutoku T,. Yoshida H, Shiratori Y, Omata M;. J Exp Med 2000;192:1601-1610.. [2]. 11447179. Epithelial Intestinal Cell Apoptosis Induced by Helicobacter. pylori Depends on Expression of the cag Pathogenicity Island. Phenotype.. Le'Negrate G, Ricci V, Hofman V, Mograbi B, Hofman P, Rossi B;. Infect Immun 2001;69:5001-5009.. [3]. 10438776. Essential components of the Ti plasmid trb system, a type IV. macromolecular transporter.. Li PL, Hwang I, Miyagi H, True H, Farrand SK;. J Bacteriol 1999;181:5033-5041. (from Pfam)

Date:

2024-08-14