Protein Family Models

This family consists of the RepA1 leader peptides. The frequency of replication of IncFII plasmid NR1 during the cell division cycle is regulated by the control of the synthesis of the plasmid-specific replication initiation protein (RepA1). When RepA1 is synthesised, it binds to the plasmid replication origin (ori) and effects the assembly of a replication complex composed of host proteins that mediate the replication of the plasmid [1]. The tap gene encodes a 24-amino acids protein. The translation of tap is required for translation of repA. [1]. 1447133. Expression of the repA1 gene of IncFII plasmid NR1 is translationally coupled to expression of an overlapping leader peptide. Wu R, Wang X, Womble DD, Rownd RH;. J Bacteriol 1992;174:7620-7628. (from Pfam)

Date:

2024-10-16

This protein is a translated leader peptide that actis in the regulation of the expression of the plasmid replication protein RepA in incF2 group plasmids.

Gene:

tap

Date:

2023-10-25