Protein Family Models

This domain is found in the C-terminal region of Shikimate 5'-dehydrogenase (SDH) present in Methanocaldococcus jannaschii. SDH catalyses the NADPH-dependent reduction of 3-dehydroshikimate to shikimate in the shikimate pathway. The domain is found just after the C-terminal domain (Pfam:PF01488) which is responsible for NADP binding [1]. [1]. 19215302. X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis. Han C, Hu T, Wu D, Qu S, Zhou J, Ding J, Shen X, Qu D, Jiang H;. FEBS J. 2009;276:1125-1139. (from Pfam)

Date:

2024-10-16

This domain is the substrate binding domain of shikimate dehydrogenase [1]. [1]. 15735308. Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae. Singh S, Korolev S, Koroleva O, Zarembinski T, Collart F, Joachimiak A, Christendat D;. J Biol Chem 2005;280:17101-17108. (from Pfam)

Date:

2024-10-16

This family contains both shikimate and quinate dehydrogenases. Shikimate 5-dehydrogenase catalyses the conversion of shikimate to 5-dehydroshikimate. This reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. Quinate 5-dehydrogenase catalyses the conversion of quinate to 5-dehydroquinate. This reaction is part of the quinate pathway where quinic acid is exploited as a source of carbon in prokaryotes and microbial eukaryotes. Both the shikimate and quinate pathways share two common pathway metabolites 3-dehydroquinate and dehydroshikimate. Discusses the pentafunctional AROM multi-domain protein, which possesses a shikimate 5-dehydrogenase enzyme. The AROM protein catalyses steps two to six in the shikimate pathway in many microbial eukaryotes. [1]. 7556173. The molecular biology of multidomain proteins. Selected examples. Hawkins AR, Lamb HK;. Eur J Biochem 1995;232:7-18. (from Pfam)

Date:

2024-10-16

shikimate dehydrogenase family protein similar to (NADP(+)) dependent shikimate dehydrogenase that catalyzes the reversible reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA), part of the chorismate biosynthesis pathway and NAD(+) dependent quinate dehydrogenase that catalyzes the conversion of L-quinate into 3-dehydroquinate, as part of the aromatic compound metabolism

Date:

2024-08-22

This HMM finds proteins from prokaryotes and functionally equivalent domains from larger, multifunctional proteins of fungi and plants. Below the trusted cutoff of 180, but above the noise cutoff of 20, are the putative shikimate dehydrogenases of Thermotoga maritima and Mycobacterium tuberculosis, and uncharacterized paralogs of shikimate dehydrogenase from E. coli and H. influenzae. The related enzyme quinate 5-dehydrogenase scores below the noise cutoff. A neighbor-joining tree, constructed with quinate 5-dehydrogenases as the outgroup, shows the Clamydial homolog as clustering among the shikimate dehydrogenases, although the sequence is unusual in the degree of sequence divergence and the presence of an additional N-terminal domain.

Gene:

aroE

Date:

2024-06-26