Protein Family Models

This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ [1-2]. [1]. 14517231. High-resolution structure of the E.coli RecQ helicase catalytic core. Bernstein DA, Zittel MC, Keck JL;. EMBO J. 2003;22:4910-4921. [2]. 19151156. Structure of the human RECQ1 helicase reveals a putative strand-separation pin. Pike AC, Shrestha B, Popuri V, Burgess-Brown N, Muzzolini L, Costantini S, Vindigni A, Gileadi O;. Proc Natl Acad Sci U S A. 2009;106:1039-1044. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. [1]. 10322435. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. de la Cruz J, Kressler D, Linder P;. Trends Biochem Sci 1999;24:192-198. [2]. 9862990. The DEAD box RNA helicase family in Arabidopsis thaliana. Aubourg S, Kreis M, Lecharny A;. Nucleic Acids Res 1999;27:628-636. (from Pfam)

Date:

2024-10-16

The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase. (from Pfam)

Date:

2024-08-14

DEAD/DEAH box containing RecQ family ATP-dependent DNA helicase catalyzes the unwinding of DNA in a 3'-5' direction, and functions in the maintenance of genome stability

Date:

2024-07-11

All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).

Date:

2021-04-27