This family includes Z-ring associated protein G from Escherichia coli (ZapG) and similar proteins predominantly found in gammaproteobacteria. ZapG is involved in cell division, cell envelope biogenesis and cell shape maintenance. It is a key regulator of cell envelope growth, playing a crucial role in coordinating cell width, elongation and division to maintain cell envelope integrity. It plays an important role in the lipopolysaccharide (LPS) assembly/transport [1-4]. This protein adopts an alpha helical configuration. [1]. 27335665. Inner Membrane Protein YhcB Interacts with RodZ Involved in Cell Shape Maintenance in Escherichia coli. Li G, Hamamoto K, Kitakawa M;. ISRN Mol Biol. 2012;2012:304021. [2]. 33895137. ZapG (YhcB/DUF1043), a novel cell division protein in gamma-proteobacteria linking the Z-ring to septal peptidoglycan synthesis. Mehla J, Liechti G, Morgenstein RM, Caufield JH, Hosseinnia A, Gagarinova A, Phanse S, Goodacre N, Brockett M, Sakhawalkar N, Babu M, Xiao R, Montelione GT, Vorobiev S, den Blaauwen T, Hunt JF, Uetz P;. J Biol Chem. 2021;296:100700. [3]. 34941903. Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth. Goodall ECA, Isom GL, Rooke JL, Pullela K, Icke C, Yang Z, Boelter G, Jones A, Warner I, Da Costa R, Zhang B, Rae J, Tan WB, Winkle M, Delhaye A, Heinz E, Collet JF, Cunningham AF, Blaskovich MA, Parton RG, Cole JA, Banzhaf M, Chng SS, Vollmer W, Bryant JA, Henderson IR;. PLoS Genet. 2021;17:e1009586. [4]. 36077106. A New Factor LapD Is Required for the Regulation of LpxC Amounts and Lipopolysaccharide Tr. TRUNCATED at 1650 bytes (from Pfam)
- Date:
- 2024-10-16