Protein Family Models

The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilised by a centrally located metal ion [1]. Separation into subunits is thought to occur after phosphorylation. [1]. 9261069. The structure of enzyme IIAlactose from Lactococcus lactis reveals a new fold and points to possible interactions of a multicomponent system. Sliz P, Engelmann R, Hengstenberg W, Pai EF;. Structure 1997;5:775-788. (from Pfam)

Date:

2024-10-16

Involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake

Gene:

chbA

Date:

2021-03-11

PTS N,N'-diacetylchitobiose transporter subunit IIA helps catalyze the phosphorylation of incoming sugar substrates leading to their translocation across the cell membrane

Date:

2022-12-12