Protein Family Models for Protein (Select 488141798) - Protein Family Models

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Items: 5

Select item 4140461.

YopT-type cysteine protease domain-containing protein

GO Terms:

Molecular Function:: cysteine-type endopeptidase activity (GO:0004197)

Date:: 2024-08-14

Family Accession:: NF015505.5
Method:: HMM

Select item 3917282.

new record, indexing in progress

Family Accession:

Select item 3510653.

new record, indexing in progress

Family Accession:

Select item 1979614.

T3SS effector cysteine protease YopT

Gene:: yopT

Date:: 2019-10-07

Family Accession:: NBR008577
Method:: BlastRule

Select item 1420175.

YopT-type cysteine protease domain-containing protein

The HMM represents a cysteine protease domain found in proteins of bacteria that include plant pathogens (Pseudomonas syringae), root nodule bacteria, and intracellular pathogens (e.g. Yersinia pestis, Haemophilus ducreyi, Pasteurella multocida, Chlamydia trachomatis) of animal hosts. The domain features a catalytic triad of Cys, His, and Asp. Sequences can be extremely divergent outside of a few well-conserved motifs, and additional members may exist that are detected by this model. YopT, a virulence effector protein of Yersinia pestis, cleaves and releases host cell Rho GTPases from the membrane, thereby disrupting the actin cytoskeleton. Members of the family from pathogenic bacteria are likely to be pathogenesis factors.

GO Terms: