Protein Family Models

Type III secretion systems are essential virulence determinants for many gram-negative bacterial pathogens. MxiH is an extracellular alpha helical needle that is required for translocation of effector proteins into host cells [1]. Once inside, the effector proteins subvert normal cell function to aid infection. The needle protein F, polymerises to form a shaft [2,3,4]. [1]. 16888041. Molecular model of a type III secretion system needle: Implications for host-cell sensing. Deane JE, Roversi P, Cordes FS, Johnson S, Kenjale R, Daniell S, Booy F, Picking WD, Picking WL, Blocker AJ, Lea SM;. Proc Natl Acad Sci U S A. 2006;103:12529-12533. [2]. 18281060. Structural characterization of the Yersinia pestis type III secretion system needle protein YscF in complex with its heterodimeric chaperone YscE/YscG. Sun P, Tropea JE, Austin BP, Cherry S, Waugh DS;. J Mol Biol. 2008;377:819-830. [3]. 22844497. The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection. Galle M, Jin S, Bogaert P, Haegman M, Vandenabeele P, Beyaert R;. PLoS One. 2012;7:e41547. [4]. 23390616. Regulation of the Yersinia type III secretion system: traffic control. Dewoody RS, Merritt PM, Marketon MM;. Front Cell Infect Microbiol. 2013;3:4. (from Pfam)

Date:

2024-10-16

This model describes protein SctF, which makes up the injection apparatus needle filament of the type III secretion system (T3SS), which is found in many Gram-negative pathogenic bacteria. Unlike some other components of T3SS, SctF does not have a close homolog in flagellar systems. Lineage-specific names for SctT in various bacteria include YscF in Yersinia, and AscF, BsaL, BscF, EscF, PscF, and SsaG elsewhere.

Gene:

sctF

Date:

2024-05-30