Protein Family Models for Protein (Select 488150882) - Protein Family Models

Select item 4220581.

The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme. [1]. 10361280. Poly(A) polymerase I of Escherichia coli: characterization of the catalytic domain, an RNA binding site and regions for the interaction with proteins involved in mRNA degradation. Raynal LC, Carpousis AJ;. Mol Microbiol. 1999;32:765-775. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF024040.5
Method:: HMM

Select item 4219472.

Probable RNA and SrmB- binding site of polymerase A

This region encompasses much of the RNA and SrmB binding motifs on polymerase A. [1]. 10361280. Poly(A) polymerase I of Escherichia coli: characterization of the catalytic domain, an RNA binding site and regions for the interaction with proteins involved in mRNA degradation. Raynal LC, Carpousis AJ;. Mol Microbiol. 1999;32:765-775. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF024041.5
Method:: HMM

Select item 4134003.

Poly A polymerase head domain

This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily. [1]. 1438224. Identification of the gene for an Escherichia coli poly(A) polymerase. Cao GJ, Sarkar N;. Proc Natl Acad Sci U S A 1992;89:10380-10384. (from Pfam)

GO Terms:

Molecular Function:: RNA binding (GO:0003723)

Biological Process:: RNA processing (GO:0006396)

Molecular Function:: nucleotidyltransferase activity (GO:0016779)

Date:: 2024-10-16

Family Accession:: NF013871.5
Method:: HMM

Select item 3993174.

new record, indexing in progress

Family Accession:

Select item 3992265.

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Family Accession:

Select item 3888756.

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Family Accession:

Select item 3633967.

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Family Accession:

Select item 3574448.

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Family Accession:

Select item 3476749.

new record, indexing in progress

Family Accession:

Select item 29654110.

polynucleotide adenylyltransferase PcnB

Polymerase that creates the 3' poly(A) tail found in some mRNA's

Gene:: pcnB

GO Terms:

Molecular Function:: RNA binding (GO:0003723)

Molecular Function:: poly(A) RNA polymerase activity (GO:1990817)

Date:: 2024-05-02

Family Accession:: NF008634.1
Method:: HMM

Select item 17878311.

new record, indexing in progress

Family Accession:

Select item 14214212.

polynucleotide adenylyltransferase PcnB

This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell [1] [2]. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well [3]. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).

Gene:: pcnB

GO Terms:

Molecular Function:: RNA binding (GO:0003723)

Biological Process:: polyadenylation-dependent RNA catabolic process (GO:0043633)

Molecular Function:: poly(A) RNA polymerase activity (GO:1990817)

Date:: 2024-06-26

Family Accession:: TIGR01942.1
Method:: HMM

Select item 6065213.

PcnB family polynucleotide adenylyltransferase

PcnB family polynucleotide adenylyltransferase, or poly(A) polymerase, creates the 3' poly(A) tail found in some mRNAs

Date:: 2018-07-26

Family Accession:: 11485433
Method:: Sparcle

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