Protein Family Models

Date:

2024-08-14

This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics [1]. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination. [1]. 10429180. Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Strunnikov AV, Jessberger R;. Eur J Biochem 1999;263:6-13. [2]. 9640531. SMC protein complexes and higher-order chromosome dynamics. Hirano T;. Curr Opin Cell Biol 1998;10:317-322. (from Pfam)

Date:

2024-10-16

SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle.

Gene:

smc

Date:

2021-04-27