Protein Family Models

Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [1]. [1]. 11435118. The crystal structure of yeast thiamin pyrophosphokinase. Baker LJ, Dorocke JA, Harris RA, Timm DE;. Structure 2001;9:539-546. (from Pfam)

Date:

2024-10-16

Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [1]. [1]. 11435118. The crystal structure of yeast thiamin pyrophosphokinase. Baker LJ, Dorocke JA, Harris RA, Timm DE;. Structure 2001;9:539-546. (from Pfam)

Date:

2024-10-16

thiamine pyrophosphokinase catalyzes the phosphorylation of thiamine to thiamine pyrophosphate

Date:

2017-06-23

This model has been revised. Originally, it described strictly eukaryotic thiamine pyrophosphokinase. However, it is now expanded to include also homologous enzymes, apparently functionally equivalent, from species that rely on thiamine pyrophosphokinase rather than thiamine-monophosphate kinase (TIGR01379) to produce the active TPP cofactor. This includes the thiamine pyrophosphokinase from Bacillus subtilis, previously designated YloS.

Date:

2021-11-19