Protein Family Models for Protein (Select 488216562) - Protein Family Models

Select item 4233611.

1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein

This family contains 1-deoxyxylulose-5-phosphate synthase (DXP synthase), an enzyme which catalyses the thiamine pyrophosphoate-dependent acyloin condensation reaction between carbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate, to yield 1-deoxy-D- xylulose-5-phosphate, a precursor in the biosynthetic pathway to isoprenoids, thiamine (vitamin B1), and pyridoxol (vitamin B6). [1]. 9371765. Identification of a thiamin-dependent synthase in Escherichia. coli required for the formation of the 1-deoxy-D-xylulose. 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.. Sprenger GA, Schorken U, Wiegert T, Grolle S, de Graaf AA,. Taylor SV, Begley TP, Bringer-Meyer S, Sahm H;. Proc Natl Acad Sci U S A. 1997;94:12857-12862. (from Pfam)

GO Terms:

Molecular Function:: 1-deoxy-D-xylulose-5-phosphate synthase activity (GO:0008661)

Biological Process:: terpenoid biosynthetic process (GO:0016114)

Date:: 2024-08-14

Family Accession:: NF024688.5
Method:: HMM

Select item 4129462.

transketolase C-terminal domain-containing protein

The C-terminal domain of transketolase has been proposed as a regulatory molecule binding site [2]. [1]. 8176731. Refined structure of transketolase from Saccharomyces cerevisiae. at 2.0 A resolution.. Nikkola M, Lindqvist Y, Schneider G;. J Mol Biol 1994;238:387-404.. [2]. 1628611. Three-dimensional structure of transketolase, a thiamine. diphosphate dependent enzyme, at 2.5 A resolution.. Lindqvist Y, Schneider G, Ermler U, Sundstrom M;. EMBO J 1992;11:2373-2379. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF014799.5
Method:: HMM

Select item 4129453.

Transketolase, pyrimidine binding domain

This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases. [1]. 8176731. Refined structure of transketolase from Saccharomyces cerevisiae. at 2.0 A resolution.. Nikkola M, Lindqvist Y, Schneider G;. J Mol Biol 1994;238:387-404.. [2]. 1628611. Three-dimensional structure of transketolase, a thiamine. diphosphate dependent enzyme, at 2.5 A resolution.. Lindqvist Y, Schneider G, Ermler U, Sundstrom M;. EMBO J 1992;11:2373-2379. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF014798.5
Method:: HMM

Select item 4118334.

Transketolase, thiamine diphosphate binding domain

This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4. Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis. [1]. 8176731. Refined structure of transketolase from Saccharomyces cerevisiae. at 2.0 A resolution.. Nikkola M, Lindqvist Y, Schneider G;. J Mol Biol 1994;238:387-404.. [2]. 1628611. Three-dimensional structure of transketolase, a thiamine. diphosphate dependent enzyme, at 2.5 A resolution.. Lindqvist Y, Schneider G, Ermler U, Sundstrom M;. EMBO J 1992;11:2373-2379. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF012670.5
Method:: HMM

Select item 3992935.