Protein Family Models

This entry represents the extracellular domain of the 7TM-HD (7TM Receptors with HD hydrolase) [1]. [1]. 12914674. Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria. Anantharaman V, Aravind L;. BMC Genomics 2003;4:34. (from Pfam)

Date:

2024-10-16

These bacterial 7TM receptor proteins have an intracellular Pfam:PF01966. This entry corresponds to the 7 helix transmembrane domain. These proteins also contain an N-terminal extracellular domain. [1]. 12914674. Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria. Anantharaman V, Aravind L;. BMC Genomics 2003;4:34. (from Pfam)

Date:

2024-10-16

HD domains are metal dependent phosphohydrolases. [1]. 9868367. The HD domain defines a new superfamily of metal-dependent phosphohydrolases. Aravind L, Koonin EV;. Trends Biochem Sci 1998;23:469-472. (from Pfam)

Date:

2024-10-16

metal-dependent HD family phosphohydrolase with a seven transmembrane region and an extracellular domain, similar to Bacillus subtilis cyclic-di-AMP phosphodiesterase PgpH

Date:

2018-09-22

This domain is found in a few known nucleotidyltransferes and in a large number of uncharacterized proteins. It contains four widely separated His residues, the second of which is part of an invariant dipeptide His-Asp in a region matched approximately by the motif HDIG. For proteins scoring above the trusted cutoff, confidence is high both that the domain is present and that the HMM produces an essentially correct alignment. Protein regions scoring between the trusted and noise cutoffs include correctly aligned domains, homologous domains in which one or more of the His residues is conserved but misaligned, and some probable false-positive hits indications of homology.

Date:

2024-01-02