Protein Family Models for Protein (Select 488255188) - Protein Family Models

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Items: 2

Select item 1483411.

exosortase/archaeosortase family protein

This model represents the most conserved region of the multitransmembrane protein family of exosortases and archaeosortases. The region includes nearly invariant motifs at the ends of three predicted transmembrane helices on the extracytoplasmic face: a Cys (often Cys-Xaa-Gly), Asn-Xaa-Xaa-Arg, and His. This model is much broader than the bacterial exosortase model (TIGR02602), and has in intended scope similar to (or broader than) Pfam model PF09721.

GO Terms:

Molecular Function:: cysteine-type endopeptidase activity (GO:0004197)

Biological Process:: protein targeting (GO:0006605)

Cellular Component:: membrane (GO:0016020)

Biological Process:: post-translational protein modification (GO:0043687)

Date:: 2024-03-21

Family Accession:: TIGR04178.1
Method:: HMM

Select item 525832.

exosortase family protein XrtG

Members of this protein family are found in a modest number of non-pathogenic Gram-positive bacteria, including three species of Lactococcus and three paralogs in Clostridium acetobutylicum. This protein appears related to the conserved core region of a family of proposed transpeptidases, exosortase (previously EpsH), thought to act on PEP-CTERM proteins. Members of the seed alignment include all exosortase proposed active site residues. However, in contrast to canonical exosortase (TIGR02602) and archaeal (TIGR03762), and cyanobacterial (TIGR03763) variants, this family has not yet been matched to a cognate PEP-CTERM-like sorting signal. This protein is assigned the gene symbol XrtG (eXosoRTase family protein of Gram-positives).