Protein Family Models

These peptidases are found in Archaea and Bacteria. The example in Lactococcus lactis, PepA, aids growth on milk [1]. Pyrococcus horikoshii contain a thermostable de-blocking aminopeptidase member of this family used commercially for N-terminal protein sequencing [2]. [1]. 8535515. A non-essential glutamyl aminopeptidase is required for optimal growth of Lactococcus lactis MG1363 in milk. l'Anson KJ, Movahedi S, Griffin HG, Gasson MJ, Mulholland F;. Microbiology 1995;141:2873-2881. [2]. 11798173. Active site of deblocking aminopeptidase from Pyrococcus horikoshii. Onoe S, Ando S, Ataka M, Ishikawa K;. Biochem Biophys Res Commun 2002;290:994-997. [3]. 10218575. Thermostable aminopeptidase from Pyrococcus horikoshii. Ando S, Ishikawa K, Ishida H, Kawarabayasi Y, Kikuchi H, Kosugi Y;. FEBS Lett 1999;447:25-28. [4]. 11980710. Tetrahedral aminopeptidase: a novel large protease complex from archaea. Franzetti B, Schoehn G, Hernandez JF, Jaquinod M, Ruigrok RW, Zaccai G;. EMBO J 2002;21:2132-2138. (from Pfam)

Date:

2024-10-16

This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification [1]. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases. [1]. 7674922. Evolutionary families of metallopeptidases. Rawlings ND, Barrett AJ;. Meth Enzymol 1995;248:183-228. (from Pfam)

Date:

2024-10-16

glutamyl aminopeptidase is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides

Date:

2020-10-28

This model represents the M42.001 clade within MEROPS family M42. M42 includes glutamyl aminopeptidase as in the present model, deblocking aminopeptidases as from Pyrococcus horikoshii and related species, and endo-1,4-beta-glucanase (cellulase M) as from Clostridium thermocellum. The current family includes

Gene:

pepA

Date:

2019-09-10