Protein Family Models

This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases [1,2]. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP, Swiss:P77826) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP, Swiss:P07650) [1]. The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer [1]. [1]. 9817849. The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation. Pugmire MJ, Ealick SE;. Structure 1998;6:1467-1479. [2]. 2199449. Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution. Walter MR, Cook WJ, Cole LB, Short SA, Koszalka GW, Krenitsky TA, Ealick SE;. J Biol Chem 1990;265:14016-14022. (from Pfam)

Date:

2024-10-16

This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase. All these proteins can transfer a phosphorylated ribose substrate. [1]. 2199449. Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution. Walter MR, Cook WJ, Cole LB, Short SA, Koszalka GW, Krenitsky TA, Ealick SE;. J Biol Chem 1990;265:14016-14022. (from Pfam)

Date:

2024-10-16

This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase. All these proteins can transfer a phosphorylated ribose substrate. [1]. 2199449. Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution. Walter MR, Cook WJ, Cole LB, Short SA, Koszalka GW, Krenitsky TA, Ealick SE;. J Biol Chem 1990;265:14016-14022. (from Pfam)

Date:

2024-10-16

Date:

2021-08-05

thymidine phosphorylase family protein similar to Mycoplasma pneumoniae thymidine phosphorylase, which catalyzes the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

Date:

2018-01-08

In general, members of this protein family are designated pyrimidine-nucleoside phosphorylase, enzyme family EC 2.4.2.2, as in Bacillus subtilis, and more narrowly as the enzyme family EC 2.4.2.4, thymidine phosphorylase (alternate name: pyrimidine phosphorylase), as in Escherichia coli. The set of proteins encompassed by this model is designated subfamily rather than equivalog for this reason; the protein name from this model should be used when TIGR02643 does not score above trusted cutoff.

Gene:

pdp

Date:

2021-04-27

Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway

Date:

2021-08-12