Protein Family Models

TrmB is an alpha-glucoside sensing transcriptional regulator. The protein is the transcriptional repressor for gene cluster encoding trehalose/maltose ABC transporter in T.litoralis and P.furiosus [1]. TrmB has lost its DNA binding domain but retained its sugar recognition site. A nonreducing glucosyl residue is shared by all substrates bound to TrmB which suggests that its a common recognition motif [1]. [1]. 16473881. Crystal structure of the sugar binding domain of the archaeal transcriptional regulator TrmB. Krug M, Lee SJ, Diederichs K, Boos W, Welte W;. J Biol Chem. 2006;281:10976-10982. (from Pfam)

Date:

2024-10-16

One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter [2] in Thermococcus litoralis. [1]. 8594196. Genetics of a novel starch utilisation pathway present in Klebsiella oxytoca. Fiedler G, Pajatsch M, Bock A;. J Mol Biol 1996;256:279-291. [2]. 12426307. TrmB, a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter from the hyperthermophilic archaeon Thermococcus litoralis. Lee SJ, Engelmann A, Horlacher R, Qu Q, Vierke G, Hebbeln C, Thomm M, Boos W;. J Biol Chem 2003;278:983-990. (from Pfam)

Date:

2024-10-16

TrmB family transcriptional regulator similar to Pyrococcus furiosus TrmB, a sugar-sensing repressor that recognizes two different operator sequences controlling the TM (Trehalose/Maltose) and the MD (Maltodextrin) operon encoding the respective ABC transporters and sugar-degrading enzymes

Date:

2017-11-15