This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119. [1]. 1646964. Crystal structure of an N-terminal fragment of the DNA gyrase B protein. Wigley DB, Davies GJ, Dodson EJ, Maxwell A, Dodson G;. Nature 1991;351:624-629. [2]. 10734094. Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center. Brino L, Urzhumtsev A, Mousli M, Bronner C, Mitschler A, Oudet P, Moras D. J Biol Chem 2000;275:9468-9475. [3]. 10575351. Isoleucine 10 is essential for DNA gyrase B function in Escherichia coli. Brino L, Bronner C, Oudet P, Mousli M. Biochimie 1999;81:973-980. [4]. 9817206. NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ. Tanaka T, Saha SK, Tomomori C, Ishima R, Liu D, Tong KI, Park H, Dutta R, Qin L, Swindells MB, Yamazaki T, Ono AM, Kainosho M, Inouye M, Ikura M. Nature 1998;396:88-92. [5]. 9657678. Identification of a residue involved in transition-state stabilization in the ATPase reaction of DNA gyrase. Smith CV, Maxwell A. Biochemistry 1998;37:9658-9667. [6]. 9230303. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Cell 1997;90:65-75. (from Pfam)
GO Terms:- Molecular Function:
- DNA binding (GO:0003677)
- Molecular Function:
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (GO:0003918)
- Molecular Function:
- ATP binding (GO:0005524)
- Biological Process:
- DNA topological change (GO:0006265)
- Date:
- 2024-10-16