Protein Family Models

This family contains proteins related to the MFS superfamily. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants [1], thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted [2]. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus). [1]. 10589984. The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1). Lemley C, Yan S, Dole VS, Madhubala R, Cunningham ML, Beverley SM, Myler PJ, Stuart KD;. Mol Biochem Parasitol 1999;104:93-105. [2]. 7984172. An amplified DNA element in Leishmania encodes potential integral membrane and nucleotide-binding proteins. Myler PJ, Lodes MJ, Merlin G, de Vos T, Stuart KD;. Mol Biochem Parasitol 1994;66:11-20. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

multidrug resistance (MDR) MFS transporter is a drug/H+ antiporter (DHA) that mediates the efflux of one or more from a variety of drugs and toxic compounds, and confer resistance to these compounds

Date:

2019-04-12