Protein Family Models

This entry includes budding yeast steryl acetyl hydrolase 1 (Say1) and fission yeast Mug180. Say1 is a a membrane-anchored deacetylase required for the deacetylation of acetylated sterols. It is involved in the resistance to eugenol and pregnenolone toxicity [1]. Mug180 has a role in meiosis [2]. [1]. 18034159. An acetylation/deacetylation cycle controls the export of sterols and steroids from S. cerevisiae. Tiwari R, Koffel R, Schneiter R;. EMBO J. 2007;26:5109-5119. [2]. 16303567. A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events. Martin-Castellanos C, Blanco M, Rozalen AE, Perez-Hidalgo L, Garcia AI, Conde F, Mata J, Ellermeier C, Davis L, San-Segundo P, Smith GR, Moreno S;. Curr Biol. 2005;15:2056-2062. (from Pfam)

Date:

2024-10-16

This catalytic domain is found in a very wide range of enzymes. [1]. 1409539. The alpha/beta hydrolase fold. Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag J, Sussman JL, Verschueren KHG, Goldman A;. Protein Eng 1992;5:197-211. (from Pfam)

Date:

2024-10-16

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Date:

2024-04-24