Protein Family Models

This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB). [1]. 8576032. Ribose catabolism of Escherichia coli: characterization of the. rpiB gene encoding ribose phosphate isomerase B and of the rpiR. gene, which is involved in regulation of rpiB expression.. Sorensen KI, Hove-Jensen B;. J Bacteriol 1996;178:1003-1011.. [2]. 16682767. Structure of ribose 5-phosphate isomerase from Plasmodium. falciparum.. Holmes MA, Buckner FS, Van Voorhis WC, Verlinde CL, Mehlin C,. Boni E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy. O, Zucker F, Schoenfeld LW, Earnest TN, Hol WG, Merritt EA;. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:427-431. (from Pfam)

Date:

2024-08-14

Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization

Gene:

lacA

Date:

2020-10-26

This family contains members from low GC gram-positive bacteria. Galactose-6-phosphate isomerase is involved in lactose catabolism by the tagatose-6-phosphate pathway.

Gene:

lacA

Date:

2024-05-29

galactose-6-phosphate isomerase subunit LacA catalyzes the formation of D-tagatose 6-phosphate from D-galactose 6-phosphate

Date:

2018-10-24

Proteins of known function in this family act as sugar (pentose and/or hexose)-phosphate isomerases, including the LacA and LacB subunits of galactose-6-phosphate isomerases from Gram-positive bacteria and RpiB. RpiB is the second ribose phosphate isomerase of E. coli. It lacks homology to RpiA, its inducer is unknown (but is not ribose), and it can be replaced by the homologous galactose-6-phosphate isomerase of Streptococcus mutans, all of which suggests that the ribose phosphate isomerase activity of RpiB is a secondary function. On the other hand, there appear to be a significant number of species which contain rpiB, lack rpiA and seem to require rpi activity in order to complete the pentose phosphate pathway.

Date:

2024-05-30