Protein Family Models

Regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes

Gene:

ahrC

Date:

2024-08-01

This is the C-terminal domain of the arginine repressor, responsible for arginine binding and multimerization [1,2]. It binds mainly Arg, but also ornithine, Pro and Tyr (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 9334747. Solution structure of the DNA-binding domain and model for the complex of multifunctional hexameric arginine repressor with DNA. Sunnerhagen M, Nilges M, Otting G, Carey J;. Nat Struct Biol 1997;4:819-826. [2]. 11856827. The structure of AhrC, the arginine repressor/activator protein from Bacillus subtilis. Dennis C CA, Glykos NM, Parsons MR, Phillips SE;. Acta Crystallogr D Biol Crystallogr. 2002;58:421-430. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

arginine repressor regulates arginine biosynthesis genes

Date:

2019-07-24

This HMM includes most members of the arginine-responsive transcriptional regulator family ArgR. This hexameric protein binds DNA at its amino end to repress arginine biosyntheis or activate arginine catabolism. Some species have several ArgR paralogs. In a neighbor-joining tree, some of these paralogous sequences show long branches and differ significantly in an otherwise well-conserved C-terminal region motif GT[VIL][AC]GDDT. These paralogs are excluded from the seed and score in the gray zone of this model, between trusted and noise cutoffs.

Gene:

argR

Date:

2024-05-15