Protein Family Models for Protein (Select 488405204) - Protein Family Models

Select item 4226591.

trypsin-like peptidase domain-containing protein

This family includes trypsin-like peptidase domains. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024758.5
Method:: HMM

Select item 4114762.

trypsin-like serine protease

GO Terms:

Molecular Function:: serine-type endopeptidase activity (GO:0004252)

Biological Process:: proteolysis (GO:0006508)

Date:: 2024-08-14

Family Accession:: NF012318.5
Method:: HMM

Select item 4114203.

Peptidase S7, Flavivirus NS3 serine protease

The viral genome is a positive strand RNA that encodes a single polyprotein precursor. Processing of the polyprotein precursor into mature proteins is carried out by the host signal peptidase and by NS3 serine protease, which requires NS2B (Pfam:PF01002) as a cofactor [4]. [1]. 7642575. Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5. Kapoor M, Zhang L, Ramachandra M, Kusukawa J, Ebner KE, Padmanabhan R;. J Biol Chem 1995;270:19100-19106. [2]. 2174669. Flavivirus genome organization, expression, and replication. Chambers TJ, Hahn CS, Galler R, Rice CM;. Annu Rev Microbiol 1990;44:649-688. [3]. 8269709. Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences. Koonin EV, Dolja VV;. Crit Rev Biochem Mol Biol 1993;28:375-430. [4]. 10026173. Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects. Murthy HM, Clum S, Padmanabhan R;. J Biol Chem 1999;274:5573-5580. (from Pfam)

GO Terms:

Molecular Function:: RNA binding (GO:0003723)

Molecular Function:: RNA helicase activity (GO:0003724)

Molecular Function:: ATP binding (GO:0005524)

Date:: 2024-10-16

Family Accession:: NF013142.5
Method:: HMM

Select item 3990714.