Protein Family Models for Protein (Select 488471961) - Protein Family Models

Select item 4192531.

This family is a member of the Alkaline phosphatase clan. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF020249.5
Method:: HMM

Select item 4132432.

This family includes phosphopentomutase Swiss:P07651 and 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, Swiss:P37689. This family is also related to Pfam:PF00245 [1]. The alignment contains the most conserved residues that are probably involved in metal binding and catalysis. [1]. 10082381. A superfamily of metalloenzymes unifies phosphopentomutase and cofactor- independent phosphoglycerate mutase with alkaline phosphatases and sulfatases. Galperin MY, Bairoch A, Koonin EV;. Protein Sci 1998;7:1829-1835. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Molecular Function:: metal ion binding (GO:0046872)

Date:: 2024-10-16

Family Accession:: NF013811.5
Method:: HMM

Select item 4124453.

alkaline phosphatase family protein

This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars [1]. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity [4]. The alignment encompasses the active site [3,4]. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum [2]. [1]. 9344668. Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes. Jin-Hua P, Goding JW, Nakamura H, Sano K;. Genomics 1997;45:412-415. [2]. 8617788. Cloning and expression of the unique Ca2+-ATPase from Flavobacterium odoratum. Peiffer WE, Desrosiers MG, Menick DR;. J Biol Chem 1996;271:5095-5100. [3]. 7730366. Affinity purification and cDNA cloning of rat neural differentiation and tumor cell surface antigen gp130RB13-6 reveals relationship to human and murine PC-1. Deissler H, Lottspeich F, Rajewsky MF;. J Biol Chem 1995;270:9849-9855. [4]. 7982964. cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. Murata J, Lee HY, Clair T, Krutzsch HC, Arestad AA, Sobel ME, Liotta LA, Stracke ML;. J Biol Chem 1994;269:30479-30484. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF013799.5
Method:: HMM

Select item 3952374.

new record, indexing in progress

Family Accession:

Select item 3902295.

new record, indexing in progress

Family Accession:

Select item 3889776.

new record, indexing in progress

Family Accession:

Select item 3476687.

new record, indexing in progress

Family Accession:

Select item 2352548.

alkaline phosphatase family protein

alkaline phosphatase family protein catalyzes the hydrolysis of phosphate monoesters or diesters, similar to ectonucleotide pyrophosphatases/phosphodiesterases (ENPPs), which hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates

Date:: 2024-10-08

Family Accession:: 11445914
Method:: Sparcle

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