Protein Family Models

This entry includes dynactin 5 (DCTN5, also known as subunit p25). Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. DCTN5 is part of the pointed-end subcomplex in dynactin that also includes p26, p27 (also known as dynactin 6), and Arp11 [1,2]. This subcomplex interacts with membranous cargoes. DCTN5 plays a dual role in cargo binding and dynactin regulation, being critical for this process. DCTN5 contains imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X) [3]. [1]. 30143531. p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation. Qiu R, Zhang J, Xiang X;. J Biol Chem. 2018;293:15606-15619. [2]. 28602352. Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated. Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP;. Cell. 2017;169:1303-1314. [3]. 15043994. Dynactins p25 and p27 are predicted to adopt the LbetaH fold. Parisi G, Fornasari MS, Echave J;. FEBS Lett. 2004;562:1-4. (from Pfam)

Date:

2024-10-16

Members of this family share a hexapeptide repeat-containing domain with acetyltransferases and succinyltransferases such as DapH, DapD, and GlmU.

Date:

2024-08-14

Date:

2024-08-14

gamma carbonic anhydrase family protein is a hexapeptide repeat protein similar to carnitine operon protein CaiE and phenylacetic acid degradation protein PaaY, which are involved in amine/polyamine and aromatic compound metabolism, respectively

Date:

2024-08-04