Protein Family Models for Protein (Select 488884933) - Protein Family Models

Select item 4312601.

Xeroderma pigmentosum group B helicase damage recognition domain

This domain is found in the N-terminal region of xeroderma pigmentosum group B (XPB) helicase present in Archaeoglobus fulgidus. XPB is essential for transcription, nucleotide excision repair, and TFIIH functional assembly. The domain is a damage recognition domain (DRD) which allows XPB to unwind damaged DNA as needed for nucleotide excision repair [1]. [1]. 16600867. Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair. Fan L, Arvai AS, Cooper PK, Iwai S, Hanaoka F, Tainer JA;. Mol Cell. 2006;22:27-37. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF037353.5
Method:: HMM

Select item 4261652.

ERCC3/RAD25/XPB C-terminal helicase

This is the C-terminal helicase domain of ERCC3, RAD25 and XPB helicases [1]. [1]. 23385459. Structure of the C-terminal half of human XPB helicase and the impact of the disease-causing mutation XP11BE. Hilario E, Li Y, Nobumori Y, Liu X, Fan L;. Acta Crystallogr D Biol Crystallogr. 2013;69:237-246. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF027528.5
Method:: HMM

Select item 4149163.

DEAD/DEAH box helicase family protein

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: ATP binding (GO:0005524)

Molecular Function:: hydrolase activity (GO:0016787)

Date:: 2024-08-14

Family Accession:: NF016724.5
Method:: HMM

Select item 4118844.

DEAD/DEAH box helicase

Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. [1]. 10322435. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. de la Cruz J, Kressler D, Linder P;. Trends Biochem Sci 1999;24:192-198. [2]. 9862990. The DEAD box RNA helicase family in Arabidopsis thaliana. Aubourg S, Kreis M, Lecharny A;. Nucleic Acids Res 1999;27:628-636. (from Pfam)

GO Terms:

Molecular Function:: nucleic acid binding (GO:0003676)

Molecular Function:: ATP binding (GO:0005524)

Date:: 2024-10-16

Family Accession:: NF012492.5
Method:: HMM

Select item 4117615.

helicase-related protein

The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF012493.5
Method:: HMM

Select item 4038596.