Protein Family Models

The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1]. [1]. 18389302. Rethinking proteasome evolution: two novel bacterial proteasomes. Valas RE, Bourne PE;. J Mol Evol. 2008;66:494-504. (from Pfam)

Date:

2024-10-16

The ATP-dependent protease HslVU, a complex of hexameric HslU active as a protein-unfolding ATPase and dodecameric HslV, the catalytic threonine protease.

Gene:

hslV

Date:

2024-06-11

ATP-dependent protease subunit HslV is the proteolytic component of the ATP-dependent protease HslVU, which catalyzes the ATP-dependent cleavage of peptide bonds with broad specificity during protein degradation

Date:

2023-03-07

Heat shock protein involved in degradation of misfolded proteins

Gene:

hslV

Date:

2021-07-28