Protein Family Models

Small, non-coding RNA molecules play important regulatory roles in a variety of physiological processes in bacteria. SgrR_N is the N-terminus of a family of proteins which regulate the transcription of these sRNAs, in particular SgrS. SgrR_N contains a helix-turn-helix motif characteristic of winged-helix DNA-binding transcriptional regulators. SgrS is a small RNA required for recovery from glucose-phosphate stress in bacteria [1]. In examining the regulation of sgrR expression it was found that SgrR negatively auto-regulates its own transcription in the presence and absence of stress, and thus SgrR coordinates the response to glucose-phosphate stress by binding specifically to sgrS promoter DNA [2]. [1]. 15522088. Involvement of a novel transcriptional activator and small RNA in post-transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase system. Vanderpool CK, Gottesman S;. Mol Microbiol. 2004;54:1076-1089. [2]. 17209026. The novel transcription factor SgrR coordinates the response to glucose-phosphate stress. Vanderpool CK, Gottesman S;. J Bacteriol. 2007;189:2238-2248. (from Pfam)

Date:

2024-10-16

The borders of this family are based on the PDBSum definitions of the domain edges for Swiss:P06202. (from Pfam)

Date:

2024-08-14

SgrR family transcriptional regulator contains an N-terminal helix-turn-helix DNA binding domain and a C-terminal ligand binding domain reminiscent of periplasmic substrate-binding domains of nickel/peptide transport systems; similar to uncharacterized Escherichia coli protein YbaE and Bacillus subtilis protein YhjP

Date:

2018-03-19