Protein Family Models

Ivy (Inhibitor of Vertebrate lysozyme) family inhibitors of vertebrate c-type lysozyme are periplasmic proteins that provide protection against lysozyme to Gram-negative pathogens. The protection can be demonstrated only if the outer membrane is compromised, as occurs in the presence of cationic antimicrobial peptide produced by host defenses. Overexpression of Ivy has been shown to have the chaperone-like function of helping to prevent aggregation of a certain proteins in the periplasm, a function that might also have physiological relevance.

Date:

2024-08-14

Ivy, an inhibitor of vertebrate C-type lysozymes, is targeted to the periplasm in Gram-negative bacteria and protects the cell wall after other host defenses have first damaged the outer member.

Gene:

ivy

Date:

2020-11-13

Ivy family C-type lysozyme inhibitor is a strong inhibitor of lysozyme C

Date:

2023-02-03