Protein Family Models

This domain is found in NifU in combination with Pfam:PF01106. This domain is found on isolated in several bacterial species such as Swiss:O53156. The nif genes are responsible for nitrogen fixation. However this domain is found in bacteria that do not fix nitrogen, so it may have a broader significance in the cell than nitrogen fixation. These proteins appear to be scaffold proteins for iron-sulfur clusters [2]. [1]. 8875867. A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution. Hwang DM, Dempsey A, Tan KT, Liew CC;. J Mol Evol 1996;43:536-540. [2]. 12970193. Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p. Muhlenhoff U, Gerber J, Richhardt N, Lill R;. EMBO J 2003;22:4815-4825. (from Pfam)

Date:

2024-10-16

iron-sulfur cluster assembly scaffold protein, such as Escherichia coli IscU, on which IscS assembles Fe-S clusters

Date:

2023-02-23

This HMM represents IscU, a homolog of the N-terminal region of NifU, an Fe-S cluster assembly protein found mostly in nitrogen-fixing bacteria. IscU is considered part of the IscSUA-hscAB-fdx system of Fe-S assembly, whereas NifU is found in nitrogenase-containing (nitrogen-fixing) species. A NifU-type protein is also found in Helicobacter and Campylobacter. IscU and NifU are considered scaffold proteins on which Fe-S clusters are assembled before transfer to apoproteins. This model excludes true NifU proteins as in Klebsiella pneumoniae and Anabaena sp. as well as archaeal homologs. It includes largely proteobacterial and eukaryotic forms.

Gene:

iscU

Date:

2024-05-30