Protein Family Models

This domain is found associated with Pfam:PF01464. It is the N-terminal structural domain of MltC (Membrane-bound lytic murein transglycosylase C), one of the seven lytic transglycosylases found in the genome of the Gram-negative bacterium Escherichia coli. The role of the N-terminal domain is suggested to be important not as a mere structural extension of the active site beyond what is seen in other lytic transglycosylases but one that creates a peptide-binding site at position +2 [1]. [1]. 24988330. Structure and cell wall cleavage by modular lytic transglycosylase MltC of Escherichia coli. Artola-Recolons C, Lee M, Bernardo-Garcia N, Blazquez B, Hesek D, Bartual SG, Mahasenan KV, Lastochkin E, Pi H, Boggess B, Meindl K, Uson I, Fisher JF, Mobashery S, Hermoso JA;. ACS Chem Biol. 2014;9:2058-2066. (from Pfam)

Date:

2024-10-16

This family is distantly related to Pfam:PF00062. Members are found in phages, type II, type III and type IV secretion systems (reviewed in [4]). [1]. 8203016. A conserved domain in putative bacterial and bacteriophage transglycosylases. Koonin EV, Rudd KE;. Trends Biochem Sci 1994;19:106-107. [2]. 8692991. A family of lysozyme-like virulence factors in bacterial pathogens of plants and animals. Mushegian AR, Fullner KJ, Koonin EV, Nester EW;. Proc Natl Acad Sci U S A 1996;93:7321-7326. [3]. 7548026. Structure of the 70-kDa soluble lytic transglycosylase complexed with bulgecin A. Implications for the enzymatic mechanism. Thunnissen AM, Rozeboom HJ, Kalk KH, Dijkstra BW;. Biochemistry 1995;34:12729-12737. [4]. 14625683. Lytic transglycosylases in macromolecular transport systems of Gram-negative bacteria. Koraimann G;. Cell Mol Life Sci 2003;60:2371-2388. (from Pfam)

Date:

2024-10-16

Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues

Gene:

mltC

Date:

2021-09-20

membrane-bound lytic murein transglycosylase C catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues

Date:

2017-02-03