Protein Family Models

This family is involved in iron-sulphur cluster biosynthesis [3]. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins [1] [2]. [1]. 10217509. Organization and expression of nitrogen-fixation genes in the aerobic nitrogen-fixing unicellular cyanobacterium Synechococcus sp. strain RF-1. Huang TC, Lin RF, Chu MK, Chen HM;. Microbiology 1999;145:743-753. [2]. 12207230. The Rhizobium etli gene iscN is highly expressed in bacteroids and required for nitrogen fixation. Dombrecht B, Tesfay MZ, Verreth C, Heusdens C, Napoles MC, Vanderleyden J, Michiels J;. Mol Genet Genomics 2002;267:820-828. [3]. 11941510. Iron-sulfur cluster biosynthesis: characterization of Schizosaccharomyces pombe Isa1. Wu G, Mansy SS, Hemann C, Hille R, Surerus KK, Cowan JA;. J Biol Inorg Chem 2002;7:526-532. (from Pfam)

Date:

2024-10-16

This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown [1]. [1]. 8048161. The modular structure of NifU proteins. Ouzounis C, Bork P, Sander C;. Trends Biochem Sci 1994;19:199-200. (from Pfam)

Date:

2024-10-16

Date:

2018-09-12

IscR (TIGR02010) is an iron-sulfur cluster-binding transcriptional regulator (see Genome Property GenProp0138). Members of this protein family include YhgI, whose expression is under control of IscR, and show sequence similarity to IscA, a known protein of iron-sulfur cluster biosynthesis. These two lines of evidence strongly suggest a role as an iron-sulfur cluster biosynthesis protein. An older study designated this protein GntY and suggested a role for it and for the product of an adjacent gene, based on complementation studies, in gluconate utilization.

Gene:

nfuA

Date:

2024-06-27

Fe/S biogenesis protein NfuA is an iron-sulphur carrier protein that may be involved in the maturation and/or repair of Fe/S proteins

Date:

2017-02-03

Gene:

nfuA

Date:

2021-10-20