Protein Family Models

This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyse the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyse the fist disaccharide step in the synthesis of lipid-A-disaccharide. [1]. 8917090. Cloning and expression of genes encoding lipid A biosynthesis from Haemophilus influenzae type b. Servos S, Khan S, Maskell D;. Gene 1996;175:137-141. [2]. 2824445. Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase. Crowell DN, Reznikoff WS, Raetz CR;. J Bacteriol 1987;169:5727-5734. (from Pfam)

Date:

2024-10-16

lipid-A-disaccharide synthase catalyzes the condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

Date:

2024-04-07

Lipid-A-disaccharide synthase catalyzes the formation of lipid A disaccharide (a precursor of lipid A) from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate. Lipid A, the innermost part of lipopolysaccharide (LPS, also called endotoxin), contains multiple acyl groups that are linked to the sugars and that insert into the outer membrane.

Gene:

lpxB

Date:

2021-04-27