Protein Family Models

This entry represents the N-terminal domain of the LpxI enzyme that is involved in biosynthesis of lipid A. Specifically it carried out the hydrolysis of UDP-2,3-diacyl- glucosamine. This step is either carried out by LpxI or LpxH [1]. This domain has a Rossmann fold. [1]. 23042606. LpxI structures reveal how a lipid A precursor is synthesized. Metzger LE 4th, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM;. Nat Struct Mol Biol. 2012;19:1132-1138. (from Pfam)

Date:

2024-10-16

This entry represents the catalytic C-terminal domain of the LpxI enzyme that is involved in biosynthesis of lipid A. Specifically it carried out the hydrolysis of UDP-2,3-diacyl- glucosamine. This step is either carried out by LpxI or LpxH [1]. This domain comprises a five-stranded mixed beta-sheet bracketed by one alpha-helix on one side and three on the other. This domain is structurally related to a superfamily that includes cytosine deaminase [1]. [1]. 23042606. LpxI structures reveal how a lipid A precursor is synthesized. Metzger LE 4th, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM;. Nat Struct Mol Biol. 2012;19:1132-1138. (from Pfam)

Gene:

lpxI

Date:

2024-10-16

LpxI family protein similar to Caulobacter vibrioides UDP-2,3-diacylglucosamine pyrophosphatase LpxI that hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to form 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the beta-P atom

Date:

2018-03-12