Protein Family Models

NADH-quinone oxidoreductase subunit 3 (Nqo3) is a component of respiratory complex I. This protein is located at the peripheral arm of the complex and consists of multiple domains. This entry represents the second ferredoxin-like domain which contains Fe4-S4 cluster, one of the redox centers of the complex [1-5]. Paper describing PDB structure 2fug. [1]. 16469879. Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus. Sazanov LA, Hinchliffe P;. Science. 2006;311:1430-1436. Paper describing PDB structure 5lc5. [2]. 27509854. Structure of mammalian respiratory complex I. Zhu J, Vinothkumar KR, Hirst J;. Nature. 2016;536:354-358. Paper describing PDB structure 5lnk. [3]. 27595392. Atomic structure of the entire mammalian mitochondrial complex I. Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M, Sazanov LA;. Nature. 2016;538:406-410. Paper describing PDB structure 5o31. [4]. 29395787. Structure of the Deactive State of Mammalian Respiratory Complex I. Blaza JN, Vinothkumar KR, Hirst J;. Structure. 2018;26:312-319. Paper describing PDB structure 5xtb. [5]. 28844695. Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2. Guo R, Zong S, Wu M, Gu J, Yang M;. Cell. 2017;170:1247-1257. (from Pfam)

Date:

2024-10-16

This entry represents the 4Fe-4S domain of NADH-ubiquinone oxidoreductase NDUFS1 from mammals and NuoG from bacteria, which are part of respiratory chain complex I [1-5]. Paper describing PDB structure 2fug. [1]. 16469879. Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus. Sazanov LA, Hinchliffe P;. Science. 2006;311:1430-1436. Paper describing PDB structure 4ydd. [2]. 26940877. Perchlorate Reductase Is Distinguished by Active Site Aromatic Gate Residues. Youngblut MD, Tsai CL, Clark IC, Carlson HK, Maglaqui AP, Gau-Pan PS, Redford SA, Wong A, Tainer JA, Coates JD;. J Biol Chem. 2016;291:9190-9202. Paper describing PDB structure 5lnk. [3]. 27595392. Atomic structure of the entire mammalian mitochondrial complex I. Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M, Sazanov LA;. Nature. 2016;538:406-410. Paper describing PDB structure 5o31. [4]. 29395787. Structure of the Deactive State of Mammalian Respiratory Complex I. Blaza JN, Vinothkumar KR, Hirst J;. Structure. 2018;26:312-319. Paper describing PDB structure 5t5i. [5]. 27846502. The methanogenic CO2 reducing-and-fixing enzyme is bifunctional and contains 46 [4Fe-4S] clusters. Wagner T, Ermler U, Shima S;. Science. 2016;354:114-117. (from Pfam)

Date:

2024-10-16

The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

Members of this family of are found at the C-terminus of NADH dehydrogenases subunit G or NADH-ubiquinone oxidoreductase subunit G. EC:1.6.99.5. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

Date:

2024-08-14

This HMM represents the G subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria while translocating protons, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This HMM excludes related subunits from formate dehydrogenase complexes.

Gene:

nuoG

Date:

2024-06-14

NuoG family protein

Date:

2017-03-02