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Links from Protein

Items: 5

1.

DNA gyrase inhibitor YacG

YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase [1]. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins [2]. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures. [1]. 18586829. YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyrase. Sengupta S, Nagaraja V;. Nucleic Acids Res. 2008;36:4310-4316. [2]. 12211008. NMR structure of the Escherichia coli protein YacG: a novel sequence motif in the zinc-finger family of proteins. Ramelot TA, Cort JR, Yee AA, Semesi A, Edwards AM, Arrowsmith CH, Kennedy MA;. Proteins. 2002;49:289-293. (from Pfam)

Gene:
yacG
GO Terms:
Molecular Function:
zinc ion binding (GO:0008270)
Date:
2024-10-16
Family Accession:
NF015821.5
Method:
HMM
2.
new record, indexing in progress
Family Accession:
3.
new record, indexing in progress
Family Accession:
4.

DNA gyrase inhibitor YacG

Gene:
yacG
GO Terms:
Biological Process:
regulation of DNA-templated transcription (GO:0006355)
Molecular Function:
zinc ion binding (GO:0008270)
Date:
2021-12-20
Family Accession:
NF002362.0
Method:
HMM
5.

DNA gyrase inhibitor YacG

DNA gyrase inhibitor YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA

Date:
2019-06-28
Family Accession:
10011674
Method:
Sparcle
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