This domain is found at the C-terminal end of Activated RNA polymerase II transcriptional coactivator p15 from humans, YdbC from Lactococcus lactis, and other PC4 family members. p15 has a bipartite structure composed of an N-terminal regulatory domain and a carboxy-terminal cryptic DNA-binding domain [1-4]. Activity is controlled by protein kinases that target the regulatory domain. [1]. 8062392. A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. Kretzschmar M, Kaiser K, Lottspeich F, Meisterernst M;. Cell 1994;78:525-534. [2]. 23303792. Structures of apo- and ssDNA-bound YdbC from Lactococcus lactis uncover the function of protein domain family DUF2128 and expand the single-stranded DNA-binding domain proteome. Rossi P, Barbieri CM, Aramini JM, Bini E, Lee HW, Janjua H, Xiao R, Acton TB, Montelione GT;. Nucleic Acids Res. 2013;41:2756-2768. [3]. 9360603. C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site. Brandsen J, Werten S, van der Vliet PC, Meisterernst M, Kroon J, Gros P;. Nat Struct Biol. 1997;4:900-903. [4]. 34534740. Insights on the disruption of the complex between human positive coactivator 4 and p53 by small molecules. Pandey B, Dev A, Chakravorty D, Bhandare VV, Polley S, Roy S, Basu G;. Biochem Biophys Res Commun. 2021;578:15-20. (from Pfam)
GO Terms:- Molecular Function:
- DNA binding (GO:0003677)
- Biological Process:
- regulation of DNA-templated transcription (GO:0006355)
- Date:
- 2024-10-16