Protein Family Models for Protein (Select 489117225) - Protein Family Models

Warning: The NCBI web site requires JavaScript to function. more...

Links from Protein

Items: 7

Select item 4197581.

hydroxymethylglutaryl-CoA synthase

GO Terms:

Molecular Function:: hydroxymethylglutaryl-CoA synthase activity (GO:0004421)

Biological Process:: acetyl-CoA metabolic process (GO:0006084)

Biological Process:: farnesyl diphosphate biosynthetic process, mevalonate pathway (GO:0010142)

Date:: 2024-08-14

Family Accession:: NF020129.5
Method:: HMM

Select item 4119552.

Hydroxymethylglutaryl-coenzyme A synthase N terminal

GO Terms:

Biological Process:: isoprenoid biosynthetic process (GO:0008299)

Date:: 2024-08-14

Family Accession:: NF013333.5
Method:: HMM

Select item 3953783.

new record, indexing in progress

Family Accession:

Select item 3889444.

new record, indexing in progress

Family Accession:

Select item 3584875.

new record, indexing in progress

Family Accession:

Select item 3484886.

new record, indexing in progress

Family Accession:

Select item 1428157.

hydroxymethylglutaryl-CoA synthase

This clade of hydroxymethylglutaryl-CoA (HMG-CoA) synthases is found in a limited spectrum of mostly gram-positive bacteria which make isopentenyl pyrophosphate (IPP) via the mevalonate pathway. This pathway is found primarily in eukaryotes and archaea, but the bacterial homologs are distinct, having aparrently diverged after being laterally transferred from an early eukaryote [1]. HMG-CoA synthase is the first step in the pathway and joins acetyl-CoA with acetoacetyl-CoA with the release of one molecule of CoA. The Borellia sequence may have resulted from a separate lateral transfer event.

GO Terms: