Protein Family Models

This family appears to be a methyltransferase domain. (from Pfam)

Date:

2024-08-14

Methyltrans_16 is a lysine methyltransferase. Characterised members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins [2,3,4,5]. [1]. 12872006. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, Dlakic M, Clarke S;. Mol Cell Proteomics 2003;2:525-540. [2]. 20975703. Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. Magnani R, Dirk LM, Trievel RC, Houtz RL;. Nat Commun. 2010;1:43. [3]. 22948820. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Kernstock S, Davydova E, Jakobsson M, Moen A, Pettersen S, Maelandsmo GM, Egge-Jacobsen W, Falnes PO;. Nat Commun. 2012;3:1038. [4]. 23349634. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, Lavallee-Adam M, Faubert D, Blanchette M, Coulombe B;. PLoS Genet. 2013;9:e1003210. [5]. 23921388. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. Jakobsson ME, Moen A, Bousset L, Egge-Jacobsen W, Kernstock S, Melki R, Falnes PO;. J Biol Chem. 2013;288:27752-27763. (from Pfam)

Date:

2024-10-16

This domain is found in ribosomal RNA small subunit methyltransferase C (eg Swiss:P44453) as well as other methyltransferases (eg Swiss:Q53742). (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

This domain is the methyltransferase domain found in ribosomal RNA large subunit methyltransferase K/L from Escherichia coli (RmlKL), tRNA (guanine(10)-N2)-dimethyltransferase from Methanocaldococcus jannaschii and similar proteins, which have a THUMP domain at the N-terminal [1-4]. [1]. 11295541. THUMP - a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases. Aravind L, Koonin EV;. Trends Biochem Sci 2001;26:215-217. [2]. 16343540. Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain. Waterman DG, Ortiz-Lombardia M, Fogg MJ, Koonin EV, Antson AA;. J Mol Biol. 2006;356:97-110. [3]. 17010378. Identification of Escherichia coli m2G methyltransferases: I. the ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA. Lesnyak DV, Sergiev PV, Bogdanov AA, Dontsova OA;. J Mol Biol. 2006;364:20-25. [4]. 22362734. Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA. Wang KT, Desmolaize B, Nan J, Zhang XW, Li LF, Douthwaite S, Su XD;. Nucleic Acids Res. 2012;40:5138-5148. (from Pfam)

Date:

2024-10-16

tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase is a class I SAM-dependent methyltransferase that specifically methylates the adenine in position 37 of tRNA(1)(Val)

Date:

2024-10-16