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iron dependent repressor, metal binding and dimerization domain protein
This family includes the Diphtheria toxin repressor [1]. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation [2]. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 7568230. Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae. Schiering N, Tao X, Zeng H, Murphy JR, Petsko GA, Ringe D;. Proc Natl Acad Sci USA 1995;92:9843-9850. [2]. 7743135. Three-dimensional structure of the diphtheria toxin repressor in complex with divalent cation co-repressors. Qiu X, Verlinde CL, Zhang S, Schmitt MP, Holmes RK, Hol WG;. Structure 1995;3:87-100. (from Pfam)
Iron dependent repressor, N-terminal DNA binding domain
This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif. [1]. 7568230. Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae. Schiering N, Tao X, Zeng H, Murphy JR, Petsko GA, Ringe D;. Proc Natl Acad Sci USA 1995;92:9843-9850. [2]. 7743135. Three-dimensional structure of the diphtheria toxin repressor in complex with divalent cation co-repressors. Qiu X, Verlinde CL, Zhang S, Schmitt MP, Holmes RK, Hol WG;. Structure 1995;3:87-100. (from Pfam)
manganese-binding transcriptional regulator MntR
manganese-binding transcriptional regulator MntR, in the presence of manganese, represses the expression of mntH and mntS, and up-regulates the expression of mntP
Transcriptional regulator that represses the manganese transporter MntH when manganese is present
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