Protein Family Models

This is a family of beta-barrel porin-like outer membrane proteins from enteropathogenic Gram-negative bacteria. Intimins and invasins are virulence factors produced by pathogenic Gram-negative bacteria. They carry C-terminal extracellular passenger domains that are involved in adhesion to host cells and N-terminal beta domains that are embedded in the outer membrane. This family represents the beta-barrel porin-like domain in the outer membrane that can be found in intimins, invasins and some inverse autotransporters [1,2]. [1]. 22658748. Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis. Fairman JW, Dautin N, Wojtowicz D, Liu W, Noinaj N, Barnard TJ, Udho E, Przytycka TM, Cherezov V, Buchanan SK;. Structure. 2012;20:1233-1243. [2]. 25596886. The inverse autotransporter family: intimin, invasin and related proteins. Leo JC, Oberhettinger P, Schutz M, Linke D;. Int J Med Microbiol. 2015;305:276-282. (from Pfam)

Date:

2024-10-16

SinH, also called SivH (Salmonella invasin homologue), is an inverse autotransporter associated with virulence.

Gene:

sinH

Date:

2020-10-26