Protein Family Models

This family includes the glycan-binding N-terminal domain (called the translocation domain) of the nicotine adenine dinucleotide glycohydrolase toxin (NADase) of Steptococcus pyogenes. Related domains are often referred to as the discoidin domain.

Date:

2024-10-02

This family consists of several bacterial nicotine adenine dinucleotide glycohydrolase (NGA) proteins which appear to be specific to Streptococcus pyogenes. NAD glycohydrolase (NADase) is a potential virulence factor. Streptococcal NADase may contribute to virulence by its ability to cleave beta-NAD at the ribose-nicotinamide bond, depleting intracellular NAD pools and producing the potent vasoactive compound nicotinamide [1]. [1]. 10979908. Molecular epidemiology of nga and NAD glycohydrolase/ADP-ribosyltransferase activity among Streptococcus pyogenes causing streptococcal toxic shock syndrome. Stevens DL, Salmi DB, McIndoo ER, Bryant AE;. J Infect Dis 2000;182:1117-1128. (from Pfam)

Date:

2024-10-16

Gene:

nga

Date:

2020-08-25