Protein Family Models

This family consists of several bacterial malonate decarboxylase delta subunit (MdcD) proteins. Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyses the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcC is the (apo) ACP subunit [1]. The family also contains the CitD family of citrate lyase acyl carrier proteins. [1]. 9208947. Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli. Hoenke S, Schmid M, Dimroth P;. Eur J Biochem 1997;246:530-538. (from Pfam)

Date:

2024-10-16

malonate decarboxylase acyl carrier protein is a subunit of malonate decarboxylase, which catalyzes the decarboxylation of malonate to acetate and carbon dioxide

Date:

2017-11-28

Date:

2020-10-26

Members of this protein family are the acyl carrier protein, also called the delta subunit, of malonate decarboxylase. This subunit has the same covalently bound prosthetic group, derived from and similar to coenzyme A, as does citrate lyase, although this protein and the acyl carrier protein of citrate lyase do not show significant sequence similarity. Both malonyl and acetyl groups are transferred to the prosthetic group for catalysis.

Gene:

mdcC

Date:

2019-09-10